Hypophosphatemia promotes lower rates of muscle ATP synthesis

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Hypophosphatemia promotes lower rates of muscle ATP synthesis

Hypophosphatemia can lead to muscle weakness and respiratory and heart failure, but the mechanism is unknown. To address this question, we noninvasively assessed rates of muscle ATP synthesis in hypophosphatemic mice by using in vivo saturation transfer [31P]-magnetic resonance spectroscopy. By using this approach, we found that basal and insulin-stimulated rates of muscle ATP synthetic flux (V...

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ژورنال

عنوان ژورنال: The FASEB Journal

سال: 2016

ISSN: 0892-6638,1530-6860

DOI: 10.1096/fj.201600473r